RESUMEN Introducción: La Pandemia COVID-19, ha tenido impactos negativos en la salud física y mental de las personas, así como las medidas adoptadas por los gobiernos, para prevenir el contagio masivo de la población como el confinamiento, el aislamiento social, el trabajo y educación virtual. Dentro de los afectados por estos cambios, se encontrarían los estudiantes universitarios del área de la salud, que además de estudiar en estas condiciones de pandemia, no han podido hacer sus prácticas de los servicios de salud. Esta situación de exposición al aislamiento, podría afectar la salud mental de los jóvenes estudiantes universitarios. Objetivo: determinar los niveles de depresión, ansiedad y estrés en estudiantes universitarios y su relación con variables sociodemográficas y las características del aislamiento social durante la Pandemia COVID-19. Métodos: Se realizó un estudio descriptivo, observacional, de corte transversal y cuantitativo, con una muestra de 818 estudiantes universitarios de facultades de ciencias de la salud, mediante el cuestionario autoadministrado DASS-21. Resultados: Los principales hallazgos fueron: una mayor prevalencia en niveles altos (severos y extremadamente severos) en la ansiedad, alcanzado casi a 4 de cada 10 de los evaluados; por otro lado, en depresión y el estrés, 2 de cada 10 de los evaluados, se encontraron en los niveles mencionados. En relación con las variables sociodemográficas, las relacionadas con el COVID-19 y aislamiento social, se hallaron diferencias estadísticamente significativas con el género (mujeres > varones), el haber tenido COVID-19 (Sí > No) y vivir con familiares como antes de la pandemia (Sí > No) obtuvieron en promedio mayores puntajes en depresión, ansiedad y estrés. Conclusión: Los estudiantes que presentaron mayor depresión, ansiedad y estrés con una diferencia significativa fueron de género femenino, con antecedentes de haber tenido Covid-19, menor contacto con familiares y haber cumplido con aislamiento social total.

ABSTRACT Introduction: The COVID-19 Pandemic has had negative impacts on the physical and mental health of people, as well as the measures adopted by governments to prevent the massive contagion of the population, such as confinement, social isolation, virtual work, and virtual education. Among those affected by these changes would be university students in the health area who, in addition to studying in these pandemic conditions, have been unable to do their health service practices. This situation of exposure to isolation could affect the mental health of young university students. Objective: To determine the levels of depression, anxiety, and stress in university students, their relationship with sociodemographic variables, and the characteristics of social isolation during the COVID-19 Pandemic. Methods: A descriptive, observational, cross-sectional, and quantitative study was carried out with a sample of 818 university students from health sciences faculties using the DASS-21 self-administered questionnaire. Results: The main findings were a higher prevalence of high levels (severe and highly severe) in anxiety, reaching almost 4 out of 10 of those evaluated; On the other hand, in depression and stress, 2 out of 10 of those evaluated were found at the mentioned levels. Concerning the sociodemographic variables, those related to COVID-19 and social isolation, statistically significant differences were found with gender (women > men), having had COVID-19 (Yes > No), and living with relatives as before. On average, the pandemic (Yes > No) obtained higher scores in depression, anxiety, and stress. Conclusion: The students who presented greater depression, anxiety, and stress with a significant difference were female, with a history of having had Covid-19, less contact with family members, and having complied with total social isolation

RESUMEN Introducción: Las enfermedades infecciosas intestinales (diarrea) son una causa importante de morbilidad y mortalidad a nivel mundial. En 2015, constituyeron la novena causa principal de muerte para todas las edades. Objetivo: describir las características epidemiológicas de la mortalidad por enfermedades infecciosas intestinales (diarreas) en Paraguay durante los años 2015 al 2019. Metodología: Estudio descriptivo, ecológico, transversal, retrospectivo, muestreo no probabilístico de casos consecutivos. Se consideraron los óbitos del CIE - 10, que incluyen al cólera (A01), fiebres tifoidea y paratifoidea (A01), shigelosis (A03), otras infecciones intestinales bacterianas (A04), otras intoxicaciones alimentarias bacterianas (A05), amebiasis (A06), otras enfermedades intestinales debidas a protozoarios (A07), infecciones intestinales debidas a virus (A08) y diarrea y gastroenteritis de presunto origen infeccioso (A09). Se utilizaron datos de acceso abierto de la página WEB de la Dirección General de Información Estratégica en Salud del MSP y BS de todos los Departamentos del país. Se calcularon tasas crudas y ajustadas (por 100.000 habitantes). Se utilizaron Excel y EPI INFO 7.0. Resultados: Se registraron 495 muertes, la mayor prevalencia fue en 2019 (tasa ajustada de 1,83) y menor en 2017 (1,36). Los meses con mayor mortalidad fueron enero y julio (9,9%). El 51,72% fueron mujeres (256), 30,91% mayores de 80 años y 28,28% (140) menores de 5 años, edad promedio 50,8, solteros 56,77% (281) y sin ningún tipo de educación 41,82% (207). El 80,61% (399) residía en área urbana. Las mayores tasas se registraron en Boquerón (33,3) y Amambay (15,2). El 95,56% (473) fueron diarreas y gastroenteritis de origen infeccioso. Discusión: Se registra alto porcentaje de mortalidad de diarreas de origen infeccioso. Los extremos de la vida constituyen la población más vulnerable.

ABSTRACT Introduction: Infectious intestinal diseases (diarrhea) are a major cause of morbidity and mortality worldwide. In 2015, it constituted the ninth leading cause of death for all ages. Objective: To describe the epidemiological characteristics of mortality due to infectious intestinal diseases (diarrhea) in Paraguay from 2015 to 2019. Methods: Descriptive, ecological, cross-sectional, retrospective, and non-probabilistic sampling of consecutive cases was performed. ICD-10 deaths included cholera (A01), typhoid and paratyphoid fever (A01), shigellosis (A03), other bacterial intestinal infections (A04), other bacterial food poisoning (A05), amebiasis (A06), other intestinal diseases due to protozoa (A07), intestinal infections due to viruses (A08), and diarrhea and gastroenteritis of presumed infectious origin (A09). Open access data were obtained from the WEB page of the General Directorate of Strategic Information in Health of the MSP and BS of all the Departments of the country. Crude and adjusted rates (per 100,000 inhabitants) were calculated. Excel and EPI INFO 7.0 were used. Results: 495 deaths were registered; the highest prevalence was in 2019 (adjusted rate of 1.83) and the lowest in 2017 (1.36). The months with the highest mortality rates were January and July (9.9%). 51.72% were women (256), 30.91% were over 80 years old and 28.28% (140) were under 5 years old, average age 50.8, single 56.77% (281) and without any type of education 41.82% (207). A total of 80.61% (399) of the respondents resided in urban areas. The highest rates were registered in Boquerón (33.3) and Amambay (15.2). Diarrhea and gastroenteritis of infectious origin accounted for 95.56% of the cases (473). Discussion: There was a high percentage of mortality from infectious diarrhea. Extremes of life were the most vulnerable populations.

Resumen Los sistemas agroforestales y la diversificación productiva son alternativas sostenibles que revierten los daños y riesgos de la agricultura convencional. Existen pocos estudios de sostenibilidad que permitan incorporarlos a proyectos destinados a aumentar la rentabilidad y mejorar el bienestar de los productores, restaurando los servicios ecosistémicos. El objetivo fue evaluar la sustentabilidad de dos sistemas agroforestales tradicionales, diversificados con cacao y vainilla, en los estados de Veracruz y Oaxaca. Se promovieron técnicas agroecológicas y estrategias de desarrollo empresarial con las familias de ambos productores. La investigación se llevó a cabo durante el periodo: febrero 2012 a julio 2020, las parcelas están ubicadas en los municipios de San Pedro Ixcatlán, Oaxaca y Papantla, Veracruz. Se utilizó la metodología del marco de evaluación de sistemas de gestión de recursos naturales. Los resultados mostraron que los estados iniciales tenían un manejo poco intensivo, bajo uso de insumos, alta diversificación y orientado a la agricultura de subsistencia. Tras la diversificación, manejo agroecológico y desarrollo empresarial, los estados de transición han mejorado en la mayoría de los indicadores de sostenibilidad. En particular la rentabilidad (índice beneficio-costo), que alcanzó 1.2 para San Pedro y 2.6 para Papantla cuando se da valor agregado a la vainilla y el cacao. Es relevante la participación de las mujeres en actividades emergentes derivadas de la diversificación y el interés de los jóvenes por continuar con actividades de transformación de materias primas y la comercialización de productos de valor agregado.

Abstract Agroforestry systems and productive diversification are sustainable alternatives that reverse the damages and risks of conventional agriculture. There are few sustainability studies that allow them to be incorporated into projects aimed at increasing profitability and improving the welfare of producers, restoring ecosystem services. The objective was to assess the sustainability of two traditional agroforestry systems, diversified with cacao and vanilla, in the states of Veracruz and Oaxaca. Agroecological techniques and business development strategies were promoted with the families of both producers. The research was carried out during the period: February 2012 to July 2020, the plots are located in the municipalities of San Pedro Ixcatlán, Oaxaca and Papantla, Veracruz. The methodology of the framework of assessment of natural resource management systems was used. The results showed that the initial states had a low intensive management, low use of inputs, high diversification and oriented to subsistence agriculture. After diversification, agroecological management and business development, transition states have improved in most sustainability indicators. In particular, profitability (benefit-cost index), which reached 1.2 for San Pedro and 2.6 for Papantla when added value is given to vanilla and cacao. The participation of women in emerging activities derived from diversification and the interest of young people to continue with activities of transformation of raw materials and the commercialization of value-added products are relevant.

The worldwide emergence of viral diseases such as Zika, Dengue, Chikungunya, West Nile and Yellow Fever urge the search for solutions to eliminate their common vector, the Aedes aegypti mosquito. This paper describes the quantitative structure-activity relationship (QSAR) and docking studies of a series of nine 3-(3-aryl-1,2,4-oxadiazol-5-yl)propionic acids (AOPA), 1-9, previously published by our group. Additionally, three new 1,2,4-oxadiazoles, 10-12, have also been synthesized, characterized and studied. The QSAR and docking studies of all compounds, 1-12, clearly indicate that larger hydrophobic substituents such as biphenyl groups attached on position 3 in 1,2,4-oxadiazoles improve the larvicidal activity. It is worthwhile to mention that nanocapsulation of compounds 10-12 were necessary to help their dissolution in water and these three new 1,2,4-oxadiazoles also exhibited approximately equal or higher larvicidal activities compared to the former prototypes at stage L4.

Resumen Objetivo: Demostrar la experiencia adquirida desde la implementación del programa de donación renal pareada, el cual aumenta un 25-30% la tasa de donación en los centros hospitalarios sin inferioridad en la sobrevida del injerto comparado con el trasplante renal de donante vivo dirigido. Método: Estudio observacional, analítico, longitudinal y prospectivo de diciembre de 2018 a julio de 2021. Se incluyeron todos los enfermos renales crónicos G5 KDIGO que en el protocolo pretrasplante resultaron HLA o ABO incompatibles con sus donantes originales y que fueron trasplantados bajo el programa de donación renal pareada. Resultados: Se realizaron 22 trasplantes renales bajo este programa. La sobrevida del injerto y del paciente a 1 año postrasplante fue del 100%. La tasa de filtración glomerular postrasplante fue de 72.5 ± 17 ml/min/1.73 m2 de superficie corporal. Fueron trasplantados exitosamente el 36.3% de pacientes hipersensibilizados. La tasa de donación intrahospitalaria aumentó un 33.33%. Conclusiones: El trasplante bajo programa de donación renal pareada constituye una modalidad real de trasplante exitoso cuando existe incompatibilidad con el donante original. La mayor utilización y la socialización de este programa pueden aumentar la tasa de trasplante renal nacional, disminuyendo la lista de espera. Nuestro hospital representa la mayor experiencia publicada en México con este programa de trasplante.

Abstract Objective: To demonstrate the experience since the transplant program under paired kidney donation implementation; program that increases the donation rate by 25-30% in hospitals with no inferior graft survival compared to directed living donor kidney transplantation. Method: Observational, analytical, longitudinal and prospective study from December 2018 to July 2021. All G5 KDIGO chronic kidney patients who were HLA or ABO incompatible with their original donors in the pretransplant protocol and who were transplanted under the paired kidney donation program, were included. Results: 22 kidney transplants were performed under this program. Survival of the graft and the patient 1 year after transplantation was 100%. The post-transplant glomerular filtration rate was 72.5 ± 17 ml/min/1.73 m2 body surface. 36.3% of hypersensitized patients were successfully transplanted. The in-hospital donation rate increased by 33.33%. Conclusions: Transplantation under the kidney paired donation program constitutes a real modality of successful transplantation when there is incompatibility with the original donor. The greater use and socialization of this program can increase the country kidney transplantation rate, reducing the waiting list. Our hospital represents the largest experience published in Mexico with this transplant program.

RESUMEN El pensamiento autónomo es uno de los pilares esenciales para el desarrollo de estudiantes capaces de dar solución a las problemáticas actuales. Por tal razón, la investigación tuvo como intencionalidad develar el sentir de los docentes de secundaria del distrito de Surco en Lima metropolitana con respecto a la investigación formativa y el pensamiento autónomo. Se trató de un estudio cualitativo, que empleó el método fenomenológico hermenéutico para la interpretación de las entrevistas realizadas a seis docentes de secundaria del distrito de Surco en Lima Metropolitana, quienes fueron escogidos a partir del cumplimiento de criterios. Los hallazgos permitieron conocer tres categorías clave dentro del discurso de los docentes: la investigación formativa: motor que promueve el aprendizaje significativo, la investigación formativa: amalgama entre lo conceptual y lo procedimental, la investigación formativa: clave para el desarrollo del pensamiento autónomo, las cuales configuraron nuevas inquietudes de estudio.

RESUMO O pensamento autônomo é um dos pilares essenciais para o desenvolvimento de alunos capazes de fornecer soluções para os problemas atuais. Por esse motivo, o objetivo da pesquisa foi desvendar os sentimentos dos professores do ensino médio do distrito de Surco, na região metropolitana de Lima, em relação à pesquisa formativa e ao pensamento autônomo. Foi um estudo qualitativo que utilizou o método fenomenológico hermenêutico para interpretar as entrevistas realizadas com seis professores do ensino médio do distrito de Surco, na região metropolitana de Lima, que foram escolhidos com base no cumprimento de critérios. Os resultados revelaram três categorias principais no discurso dos professores: pesquisa formativa: a força motriz que promove a aprendizagem significativa, pesquisa formativa: amálgama de aspectos conceituais e processuais, e pesquisa formativa: chave para o desenvolvimento do pensamento autônomo, o que deu origem a novas preocupações para estudo.

ABSTRACT Autonomous thinking is one of the essential pillars for the development of students capable of providing solutions to current problems. For this reason, the purpose of this research was to unveil the feelings of secondary school teachers in the district of Surco in metropolitan Lima with respect to formative research and autonomous thinking. It was a qualitative study, which used the hermeneutic phenomenological method for the interpretation of the interviews conducted with six secondary school teachers from the district of Surco in Metropolitan Lima, who were chosen based on the fulfillment of criteria. The findings revealed three key categories within the teachers' discourse: formative research: the engine that promotes meaningful learning, formative research: amalgam between the conceptual and the procedural, and formative research: key to the development of autonomous thinking, which shaped new study concerns.

This study aimed to evaluate the effect of gamma irradiation (GI) on the physicochemical, technological, antioxidant and microbiological characteristics of different whole sorghum flours (WSF), as well as to characterize the profile of chemical constituents by paper spray mass spectrometry (PS-MS). The doses applied interfered in the staining characteristics of the evaluated flours, providing the darkening of the same. For the other physicochemical, technological, and antioxidant parameters, no significant influence of the process was observed. The fingerprint obtained in both ionization modes had not been influenced by irradiation, being flavonoids, phenylpropanoids, amino acids, benzoic acid derivatives, carboxylic acids, and sugars tentatively identified. In microbiological terms, there was a reduction of molds, yeasts, and Bacillus cereus in irradiated WSF compared to control (non-irradiated). Therefore, the application of low doses of gamma irradiation represents an advantageous alternative for the conservation of WSF and maintenance of bioactive compounds identified by the PS-MS technique.

ABSTRACT Background . The Peruvian population during Covid-19 has been exposed to stressful and traumatic events, associated with close experiences with suffering and death; but these experiences have also generated positive psychological growth. Objective. Develop a model of structural equations to determine if coping with stress is a predictor of post-traumatic growth in a Peruvian population. Method . The design was predictive cross-sectional. 310 people participated, 58 % men and 42 % women, aged 18 to 63 years (M=31.6). The COPE-28 Spanish version (Morán et al., 2010) and the Postraumatic Growth Inventory PTGI (Tedeschi & Calhoun, 1996), adapted by Ramos-Vera et al (2021). Results . In the first model, the coping strategies religion (β=.209, p<.01), self-distraction (β=.111, p<.01) and disconnection (β=-.147, p<.05) are significant predictors and explain 14.9 % of post-traumatic growth; likewise, in the second model, spiritual coping styles (β=.209, p<.01), social support (β=.172, p<.05) and cognitive (β=.164, p<.05) are im portant predictors that explain 14.7 % of post-traumatic growth. Conclusions . The best predictor of growth is religious coping followed by distraction and disconnection. Also, spiritual coping styles, social support, and cognitive support are important predictors.

RESUMEN Antecedentes . La población peruana durante la Covid-19 ha estado expuesta a eventos es tresantes y traumáticos, asociados a experiencias cercanas con el sufrimiento y la muerte; pero estas vivencias también han generado un crecimiento psicológico positivo. Objetivo. Desarrollar un modelo de ecuaciones estructurales para determinar si el afrontamiento al estrés es un predictor del crecimiento postraumático en una población peruana. Método . El diseño fue predictivo transversal. Participaron 310 personas, 58 % varones y 42 % mujeres, de 18 a 63 años (M=31.6). Se usó el COPE-28 versión española (Morán et al., 2010) y el Postraumatic Growth Inventory PTGI (Tedeschi y Calhoun, 1996), adaptado por Ramos Vera et al. (2021). Resultados . En el primer modelo, las estrategias de afrontamiento religión (β=.209, p<,01), autodistracción (β=.111, p<,01) y desconexión (β=-.147, p<,05) son predic tores significativos y explican el 14.9 % del crecimiento postraumático; asimismo, en el se gundo modelo, los estilos de afrontamiento espiritual (β=.209, p<,01), apoyo social (β=.172, p<,05) y cognitivo (β=.164, p<,05) son predictores importantes que explican el 14.7 % del crecimiento postraumático. Conclusiones . El mejor predictor del crecimiento es el afronta miento religión seguido de distracción y desconexión. También, los estilos de afrontamiento espiritual, apoyo social y cognitivo son predictores importantes.

This study evaluated the pollutant levels (NO2, SO2, CO, and O3), air quality index (AQI) and the influence of meteorological variables and coronavirus disease (COVID-19) pandemic on the air quality in Rio de Janeiro. The data set used comprises periods before (March-April, 2019) and during pandemic (March-April, 2020). According to the AQI results, on most days, the air quality was ranked as “good”. Brazilian air quality standards for SO2, O3, and NO2 were not exceeded in any of the monitoring stations during partial lockdown, while CO exceeded in all periods in one site due to industrial emission. Comparing both periods, descriptive statistics for the meteorological parameters presented no differences, which suggests similar conditions. However, when evaluated week by week in 2020, weather conditions presented some differences that probably affected pollutant concentrations. The correlations between O3 and NO2 and some meteorological parameters indicate that variations in both favored ozone formation, since it is a photochemical process favored by temperature and solar radiation and that, in Rio de Janeiro, low NO2 concentrations lead to increased O3. The improvements on air quality during the partial lockdown may be attributed mainly to a reduction on emission sources rather than weather conditions.

RESUMEN: Objetivo: Identificar a partir de la literatura científica los cuidados de Enfermería brindados a personas con obesidad sometidas a cirugía bariátrica. Método: Revisión integrativa de la literatura, se realizaron búsquedas de julio a agosto/2021 en cuatro bases de datos: MEDLINE, LILACS, BDENF y EMBASE. La pregunta de investigación fue delimitada a través de la estrategia PICo, considerando: P - Pacientes con obesidad; I - Atención de Enfermería; Co - Pacientes obesos sometidos a cirugía bariátrica. Se elaboró la siguiente pregunta: "¿Cuáles son los principales cuidados de Enfermería en pacientes con obesidad sometidos a cirugía bariátrica?". Criterios de inclusión artículos primarios que cumplieron con la pregunta orientadora; disponible en su totalidad; durante el período de 2016 a 2021; Idiomas portugués, inglés y español. Criterios de exclusión literatura gris, estudios que no respondieron a la pregunta orientadora. Los resultados de la búsqueda fueron analizados e interpretados. Resultados: 14 artículos fueron incluidos en la síntesis de la investigación. El análisis de los resultados mostró que los cuidados de Enfermería prestados a las personas sometidas a cirugía bariátrica fueron identificados en el período preoperatorio: educación en salud sobre el procedimiento quirúrgico y posibles complicaciones; y en el postoperatorio: pautas para aliviar la ansiedad. En el período intraoperatorio no se mencionaron los procedimientos de atención. Conclusión: Considerando, por lo tanto, la presentación de resultados, los hallazgos demuestran la inequívoca necesidad e importancia de incorporar nuevas tecnologías en el cuidado de Enfermería; promover la formación de habilidades y destrezas de los integrantes del equipo, además de realizar nuevas investigaciones que permitan ampliar la actuación del equipo de Enfermería en el cuidado de los pacientes sometidos a cirugía bariátrica.

RESUMO: Objetivo: Identificar a partir da literatura científica os cuidados de Enfermagem prestados as pessoas com obesidade submetidas à cirurgia bariátrica. Método: Revisão integrativa da literatura, buscas foram realizadas em julho a agosto/2021 em quatro bases de dados: MEDLINE, LILACS, BDENF e EMBASE. Delimitou-se a questão de pesquisa por meio da estratégia PICo, considerada: P - Pacientes com obesidade; I - Cuidados de Enfermagem; Co - Obesos submetidos à cirurgia bariátrica. Elaborou-se a seguinte questão: "Quais os principais cuidados de Enfermagem em pacientes com obesidade que foram submetidos à cirurgia bariátrica?". Critérios de inclusão artigos primários que atenderam a questão norteadora; disponíveis na íntegra; durante o período de 2016 a 2021; idiomas português, inglês e espanhol. Critérios de exclusão literaturas cinzentas, estudos que não respondessem à questão norteadora. Os resultados das buscas foram analisados e interpretados. Resultados: Foram incluídos 14 artigos na síntese da pesquisa. Análise dos resultados permitiu evidenciar que os cuidados de Enfermagem prestados às pessoas submetidas à cirurgia bariátrica foram identificados nos períodos pré-operatório: educação em saúde quanto ao procedimento cirúrgico e possíveis complicações; e no pós-operatório: orientações para aliviar ansiedade. No período intraoperatório, não foram citados quais cuidados são realizados. Conclusão: Considerando, portanto, a exposição dos resultados, os achados demonstram a inequívoca necessidade e a importância da incorporação de novas tecnologias nos cuidados de Enfermagem; promover a capacitação das competências e habilidades dos integrantes da equipe, além da realização de novas pesquisas que permitam ampliar a atuação da equipe de Enfermagem no atendimento a pacientes submetidos à cirurgia bariátrica.

ABSTRACT: Objective: To identify from the scientific literature the Nursing care provided to people with obesity undergoing bariatric surgery. Method: Integrative literature review, searches were carried out from July to August/2021 in four databases: MEDLINE, LILACS, BDENF and EMBASE. The research question was delimited through the PICo strategy, considering P - Patients with obesity; I - Nursing care; Co - Obese patients undergoing bariatric surgery. The following question was elaborated: "What are the main Nursing care in patients with obesity who underwent bariatric surgery?". Inclusion criteria primary articles that met the guiding question; available in full; during the period from 2016 to 2021; Portuguese, English and Spanish languages. Exclusion criteria gray literature, studies that did not respond to the guiding question. Search results were analyzed and interpreted. Results: 14 articles were included in the research synthesis. Analysis of the results showed that the Nursing care provided to people undergoing bariatric surgery was identified in the preoperative period: health education regarding the surgical procedure and possible complications; and in the postoperative period: guidelines for relieving anxiety. In the intraoperative period, care procedures were not mentioned. Conclusion: Considering, therefore, the presentation of results, the findings demonstrate the unequivocal need for and importance of incorporating new technologies in Nursing care; promote the training of skills and abilities of team members, in addition to carrying out new research that allows expanding the performance of the Nursing team in the care of patients undergoing bariatric surgery.

RESUMEN Introducción: La COVID-19 ha cursado con una gran variabilidad clínico-epidemiológica. Objetivo: El objetivo fue describir las características sociodemográficas y clínico-epidemiológicas del COVID-19 en población de altura de Perú. Materiales y métodos: Estudio observacional y retrospectivo. La población estuvo conformada por pacientes ambulatorios con diagnóstico de COVID-19, de un establecimiento de salud del primer nivel de atención, ubicado a una altitud de 3850 m.s.n.m. Se realizó el análisis documental de los registros médicos. El análisis de datos fue descriptivo porcentual y medidas de tendencia central. Resultados: Se incluyeron en el estudio 154 pacientes, en su mayoría de sexo femenino (56,5%), grupo de edad adulto (51,3%), y ocupación ama de casa (37,0%). Los síntomas más frecuentes y de mayor duración fueron la tos (80,5%, 6,3 días), dolor de garganta (61,7%, 3,6 días) y cefalea (58,4%, 3,5 días). La clasificación clínica más frecuente fue la leve (69,5%). Las comorbilidades más habituales, fueron el embarazo (14,5%), la hipertensión arterial (8,25), y la obesidad (5,5%). La saturación de oxígeno en la etapa de adulto mayor en promedio fue la más baja (84,5), en el adolescente en promedio la más alta (90). Conclusión: Los más afectados fueron mujeres, de edad adulta y ama de casa, las comorbilidades más habituales fueron el embarazo, hipertensión arterial y obesidad, los síntomas más frecuentes y de mayor duración fueron la tos, dolor de garganta y cefalea, a mayor edad la saturación de oxígeno fue menor.

ABSTRACT Introduction: COVID-19 has shown great clinical and epidemiological variability. Objective: The aim of this study was to describe the sociodemographic and clinical-epidemiological characteristics of COVID-19 in a high-altitude population of Perú. Materials and methods: Observational and retrospective study. The population consisted of ambulatory patients diagnosed with COVID-19 from a primary care health facility located at an altitude of 3850 meters above sea level. Documentary analysis of medical records was carried out. Data analysis was descriptive in terms of percentages and measures of central tendency. Results: The study included 154 patients, mostly female (56.5%), adults (51.3%), and housewives (37.0%). The most frequent and longest-lasting symptoms were cough (80.5%, 6.3 days), sore throat (61.7%, 3.6 days), and headache (58.4%, 3.5 days). The most common clinical classification was mild (69.5%). The most common comorbidities were pregnancy (14.5%), hypertension (8.25%), and obesity (5.5%). Oxygen saturation in the elderly was on average the lowest (84.5), while in adolescents it was on average the highest (90). Conclusion: Women, adult housewives, and those with comorbidities such as pregnancy, hypertension, and obesity were most affected. The most frequent and longest-lasting symptoms were cough, sore throat, and headache. Oxygen saturation decreased with age.

ABSTRACT BACKGROUND: The prevalence of primary sclerosing cholangitis (PSC) in the general population has not yet been clearly established. The management of PSC should focus on delaying the progression of the disease and restraining its complications. The only curative therapy for the disease remains liver transplantation (LT). PSC is currently the fifth most common indication for LT and corresponds to 5% of all LT indications in adults. AIMS: Our objective is to evaluate the indications and outcomes of PSC patients undergoing LT in three liver transplantation centers in southern Brazil – Hospital Santa Isabel in Blumenau, Santa Catarina state, and Hospital das Clínicas and Hospital Nossa Senhora das Graças, in Curitiba, Parana state). METHODS: This is a longitudinal observational study of patients with PSC who underwent LT in three major Brazilian medical centers. Electronic medical records and study protocols of all patients subjected to LT from January 2011 to December 2021 were retrospectively reviewed. RESULTS: Of the 1,362 transplants performed in the three medical centers, 37 were due to PSC. Recurrence of PSC occurred in three patients (8.1%) in 3.0±2.4 years (range, 1–4 years). The 1-year and 5-year survival rates after the first LT were 83.8 and 80.6%, respectively. The 1-year and 5-year graft survival rates were, respectively, 83.8 and 74.8%. CONCLUSIONS: Our experience with LT in patients with PSC demonstrated good patient and graft survival results. Most deaths were due to common factors in patients undergoing LT.

RESUMO RACIONAL: A prevalência de colangite esclerosante primária (CEP) na população em geral ainda não foi claramente estabelecida. O manejo da CEP deve se concentrar em retardar a progressão da doença e gerenciar suas complicações. A única terapia curativa para a doença continua sendo o transplante hepático (TH). A CEP é atualmente a 5ª indicação mais comum de TH e corresponde a 5% de todas as indicações de TH em adultos OBJETIVOS: O nosso objetivo é avaliar as indicações e os resultados do transplante de fígado em pacientes com CEP submetidos a TH em três centros de transplante de fígado no sul do Brasil (Hospital Santa Isabel, Blumenau, Santa Catarina; Hospital das Clínicas, Curitiba, Paraná; e Hospital Nossa Senhora das Graças, Curitiba, Paraná). MÉTODOS: Este é um estudo observacional longitudinal de pacientes com colangite esclerosante primária que foram submetidos a transplante hepático em três grandes centros médicos brasileiros. Os prontuários eletrônicos de todos os pacientes submetidos a TH de Janeiro de 2011 a Dezembro de 2021, foram avaliados retrospectivamente. RESULTADOS: De um total de 1.362 transplantes realizados nos três centros médicos, 37 eram devidos à CEP. A recorrência de CEP ocorreu em 3 pacientes (8,1%) em 3±2,4 anos (intervalo, 1–4 anos). A taxa de sobrevida de 1 ano e 5 anos após o 1° TH foi respectivamente de 83,8 e 80,6%. As taxas de sobrevida dos enxertos em 1 ano e 5 anos foram, respectivamente, 83,8 e 74,8%. CONCLUSÕES: A nossa experiência com TH em pacientes com CEP demonstrou bons resultados de sobrevida dos pacientes e dos enxertos. A maioria dos óbitos ocorreu devido a fatores comuns em pacientes submetidos a TH.

Abstract Introduction Knee osteoarthritis (KOA) is a prevalent pathology in older adults, with physical, social and psychological impacts that reduce their quality of life. Objective Analyze the correlation between KOA in older individuals and biopsychosocial aspects such as pain, functional limitation, dependence, anxiety and depression. Methods A systematic review of English and Portuguese articles published on the Cochrane Library, PUBMED/MEDLINE, SciELO and Web of Science databases between 2016 and 2021, selected according to inclusion and exclusion criteria. Results After cross-checking specific to each database, studies were selected by reading the title (2,304), abstract (136) and full article (72), with 30 ultimately included based on the eligibility criteria. Conclusion Knee osteoarthritis has a significant negative impact on patients’ lives and is correlated with pain, functional limitation, dependence, anxiety and depression, compromising interpersonal relationships, physical and mental status and causing disability due to chronic pain, making osteoarthritis (OA) a public health issue with a high financial, physical and emotional cost for patients.

Resumo Introdução A osteoartrite de joelho é uma patologia prevalente em idosos, impactando suas vidas em um contexto físico, social e psicológico, o que ocasiona redução na qualidade de vida desses indivíduos. Objetivo Analisar a correlação entre a osteoartrite de joelho em idosos e aspectos biopsicossociais como dor, limitação funcional, dependência, ansiedade e depressão. Métodos Revisão sistemática de artigos publicados nas bases de dados Cochrane Library, PUBMED/MEDLINE, SciELO e Web of Science, entre 2016 e 2021, em português e inglês. Após isso, realizou-se a seleção dos artigos de acordo com os critérios de inclusão e exclusão. Resultados Após cruzamentos específicos em cada base, selecionaram-se os artigos por meio da leitura do título (2.304), do resumo (136) e do artigo na íntegra (72). Assim, 30 artigos foram selecionados de acordo com os critérios de elegibilidade. Conclusão Confirmou-se que a osteoartrite de joelho impacta negativamente a vida dos pacientes e está correlacionada com dor, limitação funcional, dependência, ansiedade e depressão, prejudicando as relações interpessoais, afetando condições físicas e mentais e gerando incapacidade devido à dor crônica, tornando a osteoartrite uma questão de saúde pública de alto custo financeiro, físico e emocional aos pacientes.

The demand for new advanced high strength steels (AHSS) has been increasing in the last few decades. A large part of this demand comes from automotive companies. We have produced a new complex-phase (CP) steel with 1200 MPa of mechanical resistance and 8% of elongation, called CP1200. In this paper the dilatometric and microstructural characterization of a newly produced CP1200 steel is presented. The new steel was produced by making changes to the heat treatment of the already industrially available CP1100. The microstructure was quantified using light optical microscopy (LOM) and electron backscatter diffraction (EBSD). The microstructure of both steels was compared to identify the origin of the mechanical properties improvement. A new microstructure distribution, with higher amount of bainite and smaller concentration of ferrite and martensite was identified.